MARCH4

GENE INFORMATION

? »

Gene name

MARCH4 (HGNC Symbol)

Synonyms

KIAA1399, MARCH-IV, RNF174

Description

Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

217122588 - 217236750

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144583 (version 75.37)

Entrez gene

57574

UniProt

Q9P2E8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9P2E8

Antibodypedia

MARCH4 antibodies
 

PROTEIN VIEW

? »
 
 
 
MARCH4-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MARCH4-001 ENSP00000273067
ENST00000273067
Q9P2E8
Show all »
Show » Show » 410 45.5 Yes 2