SKP2

GENE INFORMATION

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Gene name

SKP2 (HGNC Symbol)

Synonyms

FBL1, FBXL1, p45

Description

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

Chromosome

5

Cytoband

p13.2

Chromosome location (bp)

36152091 - 36184421

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145604 (version 75.37)

Entrez gene

6502

UniProt

Q13309 (UniProt - Evidence at protein level)

neXtProt

NX_Q13309

Antibodypedia

SKP2 antibodies
 

PROTEIN VIEW

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SKP2-001
 
SKP2-002
 
SKP2-004
 
SKP2-006
 
SKP2-007
 
SKP2-008
 
SKP2-009
 
SKP2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SKP2-001 ENSP00000274254
ENST00000274254
Q13309
Show all »
Show » Show » 410 46.6 No 0
SKP2-002 ENSP00000274255
ENST00000274255
Q13309
Show all »
Show » Show » 424 47.8 No 0
SKP2-004 ENSP00000426004
ENST00000509692
D6RF40
Show all »
Show » 102 11.5 No 0
SKP2-006 ENSP00000421941
ENST00000508514
D6RAG5
Show all »
Show » 217 24.7 No 0
SKP2-007 ENSP00000423188
ENST00000513151
D6R9R7
Show all »
Show » Show » 255 28.6 No 0
SKP2-008 ENSP00000426675
ENST00000513263
D6RF40
Show all »
Show » 102 11.5 No 0
SKP2-009 ENSP00000424234
ENST00000504386
H0Y9I9
Show all »
Show » Show » 80 9.2 No 0
SKP2-201 ENSP00000443492
ENST00000546211
Q13309
Show all »
Show » Show » 210 23.8 No 0