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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
IGFBP3 (HGNC Symbol) |
Synonyms |
BP-53, IBP3 |
Description |
Insulin-like growth factor binding protein 3 (HGNC Symbol) |
Entrez gene summary |
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
Chromosome |
7 |
Cytoband |
p12.3 |
Chromosome location (bp) |
45951949 - 45961473 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000146674 (version 75.37) |
Entrez gene |
3486 |
UniProt |
P17936 (UniProt - Evidence at protein level) |
neXtProt |
NX_P17936 |
Antibodypedia |
IGFBP3 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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IGFBP3-001 |
ENSP00000275521
ENST00000275521
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P17936 Show all »
« Hide
P17936 [Direct mapping]Insulin-like growth factor-binding protein 3 B4DN53 [Target identity:94%; Query identity:100%]cDNA FLJ52568, highly similar to Insulin-like growth factor-binding protein 3 B3KPF0 [Target identity:25%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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291 |
31.7 |
Yes |
0 |
IGFBP3-008 |
ENSP00000370476
ENST00000381086
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B3KWK7 Show all »
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B3KWK7 [Target identity:100%; Query identity:100%]Insulin-like growth factor binding protein 3, isoform CRA_b; Insulin-like growth factor-binding protein 3; cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 B3KPF0 [Target identity:38%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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194 |
21.8 |
No |
0 |
IGFBP3-014 |
ENSP00000389668
ENST00000448817
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C9JMX4 Show all »
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C9JMX4 [Target identity:100%; Query identity:100%]Insulin-like growth factor-binding protein 3
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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132 |
14.9 |
No |
0 |
IGFBP3-018 |
ENSP00000390298
ENST00000428530
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B3KPF0 Show all »
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B3KPF0 [Target identity:52%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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143 |
16.4 |
No |
0 |
IGFBP3-019 |
ENSP00000399116
ENST00000417621
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B3KPF0 Show all »
« Hide
B3KPF0 [Target identity:49%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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153 |
17.5 |
No |
0 |
IGFBP3-020 |
ENSP00000370473
ENST00000381083
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P17936 Show all »
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P17936 [Direct mapping]Insulin-like growth factor-binding protein 3 B3KPF0 [Target identity:25%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3
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Show »
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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297 |
32.2 |
Yes |
0 |
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