TMEM27

GENE INFORMATION

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Gene name

TMEM27 (HGNC Symbol)

Synonyms

NX17

Description

Transmembrane protein 27 (HGNC Symbol)

Entrez gene summary

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

15645441 - 15683154

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147003 (version 75.37)

Entrez gene

57393

UniProt

Q9HBJ8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBJ8

Antibodypedia

TMEM27 antibodies
 

PROTEIN VIEW

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TMEM27-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMEM27-001 ENSP00000369699
ENST00000380342
Q9HBJ8
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