UHRF2

GENE INFORMATION

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Gene name

UHRF2 (HGNC Symbol)

Synonyms

MGC33463, NIRF, RNF107, URF2

Description

Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

Chromosome

9

Cytoband

p24.1

Chromosome location (bp)

6413151 - 6507054

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147854 (version 75.37)

Entrez gene

115426

UniProt

Q96PU4 (UniProt - Evidence at protein level)

neXtProt

NX_Q96PU4

Antibodypedia

UHRF2 antibodies
 

PROTEIN VIEW

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UHRF2-001
 
UHRF2-002
 
UHRF2-003
 
UHRF2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UHRF2-001 ENSP00000434182
ENST00000468435
Q96PU4
Show all »
Show » Show » 503 56.1 No 0
UHRF2-002 ENSP00000370778
ENST00000381373
B1AL33
Show all »
Show » Show » 136 15.3 No 0
UHRF2-003 ENSP00000276893
ENST00000276893
Q96PU4
Show all »
Show » Show » 802 90 No 0
UHRF2-004 ENSP00000399217
ENST00000450508
Show » 112 12.7 No 0