PTPRJ

GENE INFORMATION

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Gene name

PTPRJ (HGNC Symbol)

Synonyms

CD148, DEP1, HPTPeta

Description

Protein tyrosine phosphatase, receptor type, J (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

48002113 - 48189670

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149177 (version 75.37)

Entrez gene

5795

UniProt

Q12913 (UniProt - Evidence at protein level)

neXtProt

NX_Q12913

Antibodypedia

PTPRJ antibodies
 

PROTEIN VIEW

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PTPRJ-001
 
PTPRJ-002
 
PTPRJ-003
 
PTPRJ-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRJ-001 ENSP00000400010
ENST00000418331
Q12913
Show all »
Show » Show » 1337 145.9 Yes 1
PTPRJ-002 ENSP00000409733
ENST00000440289
Q12913
Show all »
Show » Show » 539 57.2 Yes 0
PTPRJ-003 ENSP00000435618
ENST00000527952
E9PJ83
Show all »
Show » 147 15.1 Yes 0
PTPRJ-006 ENSP00000432686
ENST00000534219
E9PPH3
Show all »
Show » Show » 120 13.3 Yes 0