FXYD4

GENE INFORMATION

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Gene name

FXYD4 (HGNC Symbol)

Synonyms

CHIF

Description

FXYD domain containing ion transport regulator 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]

Chromosome

10

Cytoband

q11.21

Chromosome location (bp)

43867090 - 43871783

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000150201 (version 75.37)

Entrez gene

53828

UniProt

P59646 (UniProt - Evidence at transcript level)

neXtProt

NX_P59646

Antibodypedia

FXYD4 antibodies
 

PROTEIN VIEW

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FXYD4-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FXYD4-001 ENSP00000473361
ENST00000476166
P59646
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