SLC7A11

GENE INFORMATION

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Gene name

SLC7A11 (HGNC Symbol)

Synonyms

xCT

Description

Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

Chromosome

4

Cytoband

q28.3

Chromosome location (bp)

139085251 - 139163503

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151012 (version 75.37)

Entrez gene

23657

UniProt

Q9UPY5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UPY5

Antibodypedia

SLC7A11 antibodies
 

PROTEIN VIEW

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SLC7A11-001
 
SLC7A11-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC7A11-001 ENSP00000280612
ENST00000280612
Q9UPY5
Show all »
Show » Show » 501 55.4 No >9
SLC7A11-002 ENSP00000424046
ENST00000509248
H0Y9F9
Show all »
Show » Show » 75 8.6 No 0