CACNA1C - Gene info - The Human Protein Atlas

CACNA1C

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CACNA1C (HGNC Symbol)
Synonyms	CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS
Description	Calcium channel, voltage-dependent, L type, alpha 1C subunit (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	2079952 - 2802108
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151067 (version 75.37)
Entrez gene	775
UniProt	Q13936 (UniProt - Evidence at protein level)
neXtProt	NX_Q13936
Antibodypedia	CACNA1C antibodies

PROTEIN VIEW

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CACNA1C-001		CACNA1C-002		CACNA1C-003		CACNA1C-004		CACNA1C-005		CACNA1C-006		CACNA1C-007		CACNA1C-008		CACNA1C-010		CACNA1C-011		CACNA1C-012		CACNA1C-013		CACNA1C-015		CACNA1C-017		CACNA1C-018		CACNA1C-019		CACNA1C-020		CACNA1C-021		CACNA1C-022		CACNA1C-023		CACNA1C-024		CACNA1C-031		CACNA1C-032		CACNA1C-034

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA1C-001	ENSP00000382563 ENST00000399655	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2138	239.6	No	>9
CACNA1C-002	ENSP00000382504 ENST00000399595	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2146	240.4	No	>9
CACNA1C-003	ENSP00000382552 ENST00000399644	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2138	239.5	No	>9
CACNA1C-004	ENSP00000382547 ENST00000399638	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2166	242.8	No	>9
CACNA1C-005	ENSP00000382506 ENST00000399597	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2138	239.7	No	>9
CACNA1C-006	ENSP00000382530 ENST00000399621	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2157	241.6	No	>9
CACNA1C-007	ENSP00000382546 ENST00000399637	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2157	241.5	No	>9
CACNA1C-008	ENSP00000382500 ENST00000399591	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2146	240.3	No	>9
CACNA1C-010	ENSP00000382549 ENST00000399641	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2138	239.5	No	>9
CACNA1C-011	ENSP00000382512 ENST00000399603	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2138	239.7	No	>9
CACNA1C-012	ENSP00000382542 ENST00000399634	E9PDI6 Show all » « Hide E9PDI6 [Target identity:100%; Query identity:100%] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014)	Show » « Hide GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport]	2209	247.1	No	>9
CACNA1C-013	ENSP00000382526 ENST00000399617	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2173	243.6	No	>9
CACNA1C-015	ENSP00000336982 ENST00000335762	F5H522 Show all » « Hide F5H522 [Target identity:100%; Query identity:100%] Voltage-dependent L-type calcium channel subunit alpha-1C Q5V9X9 [Target identity:9%; Query identity:100%] Voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 9* Q86XX1 [Target identity:5%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014)	Show » « Hide GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport]	2163	242.4	No	>9
CACNA1C-017	ENSP00000266376 ENST00000347598	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006939 [smooth muscle contraction] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2186	245	No	>9
CACNA1C-018	ENSP00000437936 ENST00000480911	F5H638 Show all » « Hide F5H638 [Target identity:100%; Query identity:100%] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:6%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014)	Show » « Hide GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport]	1279	144.7	No	>9
CACNA1C-019	ENSP00000382515 ENST00000399606	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2158	241.9	No	>9
CACNA1C-020	ENSP00000382510 ENST00000399601	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2138	239.5	No	>9
CACNA1C-021	ENSP00000341092 ENST00000344100	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2179	243.7	No	>9
CACNA1C-022	ENSP00000382537 ENST00000399629	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2155	241.5	No	>9
CACNA1C-023	ENSP00000329877 ENST00000327702	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2173	243.4	No	>9
CACNA1C-024	ENSP00000382557 ENST00000399649	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2144	240.2	No	>9
CACNA1C-031	ENSP00000385896 ENST00000406454	F5GY28 Show all » « Hide F5GY28 [Target identity:100%; Query identity:100%] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014)	Show » « Hide GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport]	2209	247.2	No	>9
CACNA1C-032	ENSP00000385724 ENST00000402845	Q13936 Show all » « Hide Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Q86XX0 [Target identity:4%; Query identity:100%] Voltage-dependent L-type calcium channel alpha 1C subunit O95234 [Target identity:1%; Query identity:100%] Calcium channel L-type alpha 1 subunit	Show » « Hide >9TM proteins predicted by MDM TMHMM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted membrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based # TM segments-based Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral to membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]	2157	241.6	No	>9
CACNA1C-034	ENSP00000445849 ENST00000543114	F5H0X0 Show all » « Hide F5H0X0 [Target identity:100%; Query identity:100%] Voltage-dependent L-type calcium channel subunit alpha-1C	Show » « Hide Protein evidence (Kim et al 2014)	Show » « Hide GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex]	100	10.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.