QDPR

GENE INFORMATION

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Gene name

QDPR (HGNC Symbol)

Synonyms

DHPR, PKU2, SDR33C1

Description

Quinoid dihydropteridine reductase (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p15.32

Chromosome location (bp)

17461884 - 17513857

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151552 (version 75.37)

Entrez gene

5860

UniProt

P09417 (UniProt - Evidence at protein level)

neXtProt

NX_P09417

Antibodypedia

QDPR antibodies
 

PROTEIN VIEW

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QDPR-001
 
QDPR-002
 
QDPR-003
 
QDPR-005
 
QDPR-006
 
QDPR-007
 
QDPR-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

QDPR-001 ENSP00000281243
ENST00000281243
P09417
Show all »
Show » Show » 244 25.8 No 0
QDPR-002 ENSP00000390944
ENST00000428702
B3KW71
Show all »
Show » Show » 213 22.4 No 0
QDPR-003 ENSP00000423227
ENST00000507439
B7Z415
Show all »
Show » 152 16 No 0
QDPR-005 ENSP00000426039
ENST00000514300
D6RHJ7
Show all »
Show » 36 3.8 No 0
QDPR-006 ENSP00000426377
ENST00000508623
D6RGG7
Show all »
Show » 162 17 No 0
QDPR-007 ENSP00000420873
ENST00000505710
Show » 128 13.6 No 0
QDPR-010 ENSP00000422759
ENST00000513615
B7Z415
Show all »
Show » 152 16 No 0