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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
ATP5J (HGNC Symbol) |
Synonyms |
ATP5, ATP5A, ATPM, CF6 |
Description |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (HGNC Symbol) |
Entrez gene summary |
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.[provided by RefSeq, Jun 2010] |
Chromosome |
21 |
Cytoband |
q21.3 |
Chromosome location (bp) |
27088815 - 27107984 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000154723 (version 75.37) |
Entrez gene |
522 |
UniProt |
P18859 (UniProt - Evidence at protein level) |
neXtProt |
NX_P18859 |
Antibodypedia |
ATP5J antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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ATP5J-001 |
ENSP00000284971
ENST00000284971
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P18859 Show all »
« Hide
P18859 [Direct mapping]ATP synthase-coupling factor 6, mitochondrial Q6IB54 [Target identity:100%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
« Hide
Plasma proteins Mitochondrial proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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108 |
12.6 |
No |
0 |
ATP5J-002 |
ENSP00000382965
ENST00000400093
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P18859 Show all »
« Hide
P18859 [Direct mapping]ATP synthase-coupling factor 6, mitochondrial Q6IB54 [Target identity:100%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
« Hide
Plasma proteins Mitochondrial proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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108 |
12.6 |
No |
0 |
ATP5J-003 |
ENSP00000389649
ENST00000457143
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P18859 Show all »
« Hide
P18859 [Direct mapping]ATP synthase-coupling factor 6, mitochondrial Q6IB54 [Target identity:93%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
« Hide
Plasma proteins Mitochondrial proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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116 |
13.4 |
No |
0 |
ATP5J-004 |
ENSP00000382971
ENST00000400099
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A8MUH2 Show all »
« Hide
A8MUH2 [Target identity:100%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005739 [mitochondrion] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport]
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119 |
14 |
No |
0 |
ATP5J-005 |
ENSP00000382962
ENST00000400090
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P18859 Show all »
« Hide
P18859 [Direct mapping]ATP synthase-coupling factor 6, mitochondrial Q6IB54 [Target identity:100%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
« Hide
Plasma proteins Mitochondrial proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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108 |
12.6 |
No |
0 |
ATP5J-006 |
ENSP00000382959
ENST00000400087
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P18859 Show all »
« Hide
P18859 [Direct mapping]ATP synthase-coupling factor 6, mitochondrial Q6IB54 [Target identity:100%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
« Hide
Plasma proteins Mitochondrial proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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108 |
12.6 |
No |
0 |
ATP5J-007 |
ENSP00000382966
ENST00000400094
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P18859 Show all »
« Hide
P18859 [Direct mapping]ATP synthase-coupling factor 6, mitochondrial Q6IB54 [Target identity:100%; Query identity:100%]ATP synthase-coupling factor 6, mitochondrial
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Show »
« Hide
Plasma proteins Mitochondrial proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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108 |
12.6 |
No |
0 |
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