Expression of FLCN in cancer - Staining overview

The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.

The cancers can be ordered histologically or alphabetically.

For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.

At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the literature conformity for the staining pattern revealed by that specific antibody.

Antibody HPA028760

Antibody CAB015158

Tissue

Antibody staining

Summary

Weak to moderate cytoplasmic positivity was observed in most malignancies. Malignant lymphomas and female genital cancers were generally negative.

Malignant tissues were generally weakly to moderately stained in the cytoplasm. Squamous cell carcinomas of cervix, lobular breast carcinomas and cystadenocarcinomas of ovary were mainly negative. Many negative cases were also noted in malignant lymphomas, malignant gliomas and endometrial adenocarcinomas.

Literature conformity

Consistent with extensive gene/protein characterization data

Partly consistent with extensive gene/protein characterization data

Level of antibody staining/expression

High
Medium
Low
Not detected

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.