OTOA

GENE INFORMATION

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Gene name

OTOA (HGNC Symbol)

Synonyms

CT108, DFNB22

Description

Otoancorin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

16

Cytoband

p12.2

Chromosome location (bp)

21689835 - 21772050

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000155719 (version 75.37)

Entrez gene

146183

UniProt

Q7RTW8 (UniProt - Evidence at protein level)

neXtProt

NX_Q7RTW8

Antibodypedia

OTOA antibodies
 

PROTEIN VIEW

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OTOA-001
 
OTOA-002
 
OTOA-003
 
OTOA-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OTOA-001 ENSP00000373610
ENST00000388958
Q7RTW8
Show all »
Show » Show » 1139 126.9 Yes 0
OTOA-002 ENSP00000373608
ENST00000388956
Q7RTW8
Show all »
Show » Show » 1060 117.9 No 0
OTOA-003 ENSP00000286149
ENST00000286149
Q7RTW8
Show all »
Show » Show » 1153 128.5 Yes 0
OTOA-004 ENSP00000373609
ENST00000388957
Q7RTW8
Show all »
Show » Show » 815 89.9 No 0