FBXO32

GENE INFORMATION

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Gene name

FBXO32 (HGNC Symbol)

Synonyms

ATROGIN1, Fbx32, MAFbx

Description

F-box protein 32 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Chromosome

8

Cytoband

q24.13

Chromosome location (bp)

124510129 - 124553446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156804 (version 75.37)

Entrez gene

114907

UniProt

Q969P5 (UniProt - Evidence at protein level)

neXtProt

NX_Q969P5

Antibodypedia

FBXO32 antibodies
 

PROTEIN VIEW

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FBXO32-001
 
FBXO32-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXO32-001 ENSP00000428205
ENST00000517956
Q969P5
Show all »
Show » 355 41.6 No 0
FBXO32-003 ENSP00000390790
ENST00000443022
Q969P5
Show all »
Show » 262 30.8 No 0