SSX2B

GENE INFORMATION

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Gene name

SSX2B (HGNC Symbol)

Synonyms

CT5.2b

Description

Synovial sarcoma, X breakpoint 2B (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

Chromosome

X

Cytoband

p11.22

Chromosome location (bp)

52780318 - 52790617

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157950 (version 75.37)

Entrez gene

727837

UniProt

Q16385 (UniProt - Evidence at protein level)

neXtProt

NX_Q16385

Antibodypedia

SSX2B antibodies
 

PROTEIN VIEW

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SSX2B-001
 
SSX2B-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SSX2B-001 ENSP00000276049
ENST00000276049
Q16385
Show all »
Show » Show » 223 25.2 No 0
SSX2B-002 ENSP00000364665
ENST00000375515
Q16385
Show all »
Show » Show » 188 21.6 No 0