TNNI1

GENE INFORMATION

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Gene name

TNNI1

Synonyms

Description

Troponin I type 1 (skeletal, slow) (HGNC Symbol)

Entrez gene summary

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

201373625 - 201398994

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159173 (version 75.37)

Entrez gene

7135

UniProt

P19237 (UniProt - Evidence at protein level)

neXtProt

NX_P19237

Antibodypedia

TNNI1 antibodies
 

PROTEIN VIEW

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TNNI1-001
 
TNNI1-002
 
TNNI1-003
 
TNNI1-004
 
TNNI1-005
 
TNNI1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNNI1-001 ENSP00000354488
ENST00000361379
P19237
Show all »
Show » Show » 187 21.7 No 0
TNNI1-002 ENSP00000337022
ENST00000336092
P19237
Show all »
Show » Show » 187 21.7 No 0
TNNI1-003 ENSP00000356281
ENST00000367312
P19237
Show all »
Show » Show » 187 21.7 No 0
TNNI1-004 ENSP00000451776
ENST00000556362
G3V4F8
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Show » Show » 137 16 No 0
TNNI1-005 ENSP00000451660
ENST00000555340
G3V489
Show all »
Show » Show » 131 15.3 No 0
TNNI1-006 ENSP00000451307
ENST00000555948
G3V3L5
Show all »
Show » Show » 105 12.1 No 0