SIM2

GENE INFORMATION

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Gene name

SIM2 (HGNC Symbol)

Synonyms

bHLHe15, MGC119447, SIM

Description

Single-minded family bHLH transcription factor 2 (HGNC Symbol)

Entrez gene summary

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

21

Cytoband

q22.13

Chromosome location (bp)

38071433 - 38122218

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159263 (version 75.37)

Entrez gene

6493

UniProt

Q14190 (UniProt - Evidence at protein level)

neXtProt

NX_Q14190

Antibodypedia

SIM2 antibodies
 

PROTEIN VIEW

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SIM2-001
 
SIM2-004
 
SIM2-005
 
SIM2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIM2-001 ENSP00000290399
ENST00000290399
Q14190
Show all »
Show » Show » 667 73.2 No 0
SIM2-004 ENSP00000392003
ENST00000431229
Show » 480 53.7 No 0
SIM2-005 ENSP00000476273
ENST00000483178
Show » 73 8.3 No 0
SIM2-201 ENSP00000404176
ENST00000430056
Q14190
Show all »
Show » Show » 570 63.5 No 0