CES5A

GENE INFORMATION

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Gene name

CES5A (HGNC Symbol)

Synonyms

CAUXIN, CES4C1, CES5, CES7, FLJ31547

Description

Carboxylesterase 5A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

16

Cytoband

q12.2

Chromosome location (bp)

55880066 - 55989943

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159398 (version 75.37)

Entrez gene

221223

UniProt

Q6NT32 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6NT32

Antibodypedia

CES5A antibodies
 

PROTEIN VIEW

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CES5A-001
 
CES5A-002
 
CES5A-003
 
CES5A-004
 
CES5A-005
 
CES5A-006
 
CES5A-011
 
CES5A-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CES5A-001 ENSP00000324271
ENST00000319165
Q6NT32
Show all »
Show » Show » 525 58.2 Yes 0
CES5A-002 ENSP00000290567
ENST00000290567
Q6NT32
Show all »
Show » Show » 575 63.9 Yes 0
CES5A-003 ENSP00000461804
ENST00000521228
I3NI11
Show all »
Show » 78 8.5 No 0
CES5A-004 ENSP00000428864
ENST00000521992
Q6NT32
Show all »
Show » Show » 604 67.5 No 0
CES5A-005 ENSP00000428571
ENST00000518005
Q6NT32
Show all »
Show » Show » 469 52.3 No 0
CES5A-006 ENSP00000428887
ENST00000520435
E5RFG9
Show all »
Show » Show » 545 60.6 Yes 0
CES5A-011 ENSP00000439810
ENST00000536025
F5H0J7
Show all »
Show » 75 8.1 No 0
CES5A-012 ENSP00000461117
ENST00000544479
Show » 47 5.1 No 0