DFFA

GENE INFORMATION

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Gene name

DFFA (HGNC Symbol)

Synonyms

DFF-45, DFF1, DFF45, ICAD

Description

DNA fragmentation factor, 45kDa, alpha polypeptide (HGNC Symbol)

Entrez gene summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

10516579 - 10532583

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160049 (version 75.37)

Entrez gene

1676

UniProt

O00273 (UniProt - Evidence at protein level)

neXtProt

NX_O00273

Antibodypedia

DFFA antibodies
 

PROTEIN VIEW

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DFFA-001
 
DFFA-002
 
DFFA-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DFFA-001 ENSP00000366237
ENST00000377038
O00273
Show all »
Show » Show » 331 36.5 No 0
DFFA-002 ENSP00000366235
ENST00000377036
O00273
Show all »
Show » Show » 268 29.4 No 0
DFFA-003 ENSP00000468395
ENST00000476658
K7ERT1
Show all »
Show » Show » 159 17.6 No 0