TFF3

GENE INFORMATION

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Gene name

TFF3 (HGNC Symbol)

Synonyms

HITF, ITF

Description

Trefoil factor 3 (intestinal) (HGNC Symbol)

Entrez gene summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

43731777 - 43735761

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160180 (version 75.37)

Entrez gene

7033

UniProt

Q07654 (UniProt - Evidence at protein level)

neXtProt

NX_Q07654

Antibodypedia

TFF3 antibodies
 

PROTEIN VIEW

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TFF3-001
 
TFF3-002
 
TFF3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TFF3-001 ENSP00000430690
ENST00000518498
Q07654
Show all »
Show » Show » 94 10.2 Yes 0
TFF3-002 ENSP00000381462
ENST00000398431
Show » 125 12.8 No 0
TFF3-201 ENSP00000291525
ENST00000291525
Show » Show » 130 14.3 No 1