SH2B2

GENE INFORMATION

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Gene name

SH2B2 (HGNC Symbol)

Synonyms

APS

Description

SH2B adaptor protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

101928405 - 101962178

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160999 (version 75.37)

Entrez gene

10603

UniProt

O14492 (UniProt - Evidence at protein level)

neXtProt

NX_O14492

Antibodypedia

SH2B2 antibodies
 

PROTEIN VIEW

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SH2B2-001
 
SH2B2-002
 
SH2B2-201
 
SH2B2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH2B2-001 ENSP00000401883
ENST00000444095
C9JK89
Show all »
Show » 308 33.7 No 0
SH2B2-002 ENSP00000415306
ENST00000432527
Show » 237 25 No 0
SH2B2-201 ENSP00000304701
ENST00000306803
O14492
Show all »
Show » 631 67.6 No 0
SH2B2-202 ENSP00000440273
ENST00000536178
F5GY53
Show all »
Show » 671 72.4 No 0