SHANK1 - Gene info - The Human Protein Atlas

Gene name

SHANK1 (HGNC Symbol)

Synonyms

SPANK-1, SSTRIP, synamon

Description

SH3 and multiple ankyrin repeat domains 1 (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

q13.33

Chromosome location (bp)

51165084 - 51222707

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161681 (version 75.37)

Entrez gene

50944

UniProt

Q9Y566 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SHANK1-001

ENSP00000293441
ENST00000293441

Q9Y566
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Q9Y566 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1

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Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007616 [long-term memory]
GO:0008022 [protein C-terminus binding]
GO:0008306 [associative learning]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030160 [GKAP/Homer scaffold activity]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031877 [somatostatin receptor binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032403 [protein complex binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0042048 [olfactory behavior]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046959 [habituation]
GO:0050885 [neuromuscular process controlling balance]
GO:0050894 [determination of affect]
GO:0060013 [righting reflex]
GO:0060074 [synapse maturation]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071532 [ankyrin repeat binding]
GO:0071625 [vocalization behavior]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic membrane potential]

2161

225

SHANK1-002

ENSP00000375690
ENST00000391814

H9KV90
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H9KV90 [Target identity:100%; Query identity:100%]
SH3 and multiple ankyrin repeat domains protein 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

2169

225.9

SHANK1-003

ENSP00000375689
ENST00000391813

Q9Y566
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Q9Y566 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1

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Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007616 [long-term memory]
GO:0008022 [protein C-terminus binding]
GO:0008306 [associative learning]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030160 [GKAP/Homer scaffold activity]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031877 [somatostatin receptor binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032403 [protein complex binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0042048 [olfactory behavior]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045211 [postsynaptic membrane]
GO:0046959 [habituation]
GO:0050885 [neuromuscular process controlling balance]
GO:0050894 [determination of affect]
GO:0060013 [righting reflex]
GO:0060074 [synapse maturation]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071532 [ankyrin repeat binding]
GO:0071625 [vocalization behavior]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic membrane potential]

1548

158.8

SHANK1-006

ENSP00000469719
ENST00000468654

M0QYB5
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M0QYB5 [Target identity:100%; Query identity:100%]
SH3 and multiple ankyrin repeat domains protein 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

183

17.9

SHANK1-008

ENSP00000351984
ENST00000359082

Q9Y566
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Q9Y566 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1

Show » « Hide

Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007616 [long-term memory]
GO:0008022 [protein C-terminus binding]
GO:0008306 [associative learning]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030160 [GKAP/Homer scaffold activity]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031877 [somatostatin receptor binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032403 [protein complex binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0042048 [olfactory behavior]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045211 [postsynaptic membrane]
GO:0046959 [habituation]
GO:0050885 [neuromuscular process controlling balance]
GO:0050894 [determination of affect]
GO:0060013 [righting reflex]
GO:0060074 [synapse maturation]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071532 [ankyrin repeat binding]
GO:0071625 [vocalization behavior]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic membrane potential]

2152

224.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.