RPS6KA4 - Gene info - The Human Protein Atlas

Gene name

RPS6KA4 (HGNC Symbol)

Synonyms

MSK2, RSK-B

Description

Ribosomal protein S6 kinase, 90kDa, polypeptide 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q13.1

Chromosome location (bp)

64126620 - 64139687

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162302 (version 75.37)

Entrez gene

8986

UniProt

O75676 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPS6KA4-001

ENSP00000333896
ENST00000334205

O75676
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O75676 [Direct mapping]
Ribosomal protein S6 kinase alpha-4
A0PJF8 [Target identity:72%; Query identity:100%]
RPS6KA4 protein

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   Transferases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Enzymes
   ENZYME proteins
   Kinases
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007411 [axon guidance]
GO:0009103 [lipopolysaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016572 [histone phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0035066 [positive regulation of histone acetylation]
GO:0035556 [intracellular signal transduction]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070498 [interleukin-1-mediated signaling pathway]

772

85.6

RPS6KA4-002

ENSP00000435580
ENST00000528057

E9PJN1
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E9PJN1 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009103 [lipopolysaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0035556 [intracellular signal transduction]

765

84.8

RPS6KA4-003

ENSP00000432945
ENST00000530504

O75676
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O75676 [Direct mapping]
Ribosomal protein S6 kinase alpha-4

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705

78.5

RPS6KA4-005

ENSP00000435314
ENST00000528355

E9PKU3
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E9PKU3 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-4

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.2

RPS6KA4-201

ENSP00000294261
ENST00000294261

G3XAA9
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G3XAA9 [Target identity:100%; Query identity:100%]
Ribosomal protein S6 kinase alpha-4; Ribosomal protein S6 kinase, 90kDa, polypeptide 4, isoform CRA_c

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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

524

58.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.