VCAM1 - Gene info - The Human Protein Atlas

Gene name

VCAM1 (HGNC Symbol)

Synonyms

CD106

Description

Vascular cell adhesion molecule 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Chromosome

Cytoband

p21.2

Chromosome location (bp)

101185298 - 101204601

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162692 (version 75.37)

Entrez gene

7412

UniProt

P19320 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VCAM1-001

ENSP00000294728
ENST00000294728

P19320
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P19320 [Direct mapping]
Vascular cell adhesion protein 1
F8UU18 [Target identity:26%; Query identity:100%]
Vascular cell adhesion molecule 1
G0ZI12 [Target identity:26%; Query identity:100%]
Vascular cell adhesion molecule 1
F2YYR6 [Target identity:24%; Query identity:100%]
Vascular cell adhesion molecule 1
F8UV74 [Target identity:19%; Query identity:100%]
Vascular cell adhesion molecule 1
Q68DC4 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp779G2333
G0ZFQ0 [Target identity:2%; Query identity:100%]
Vascular cell adhesion molecule 1

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   1TM proteins predicted by MDM
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
CD markers
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001666 [response to hypoxia]
GO:0002102 [podosome]
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0007155 [cell adhesion]
GO:0007157 [heterophilic cell-cell adhesion]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010043 [response to zinc ion]
GO:0010212 [response to ionizing radiation]
GO:0016021 [integral to membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022614 [membrane to membrane docking]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0032496 [response to lipopolysaccharide]
GO:0035094 [response to nicotine]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042383 [sarcolemma]
GO:0045177 [apical part of cell]
GO:0045471 [response to ethanol]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0060326 [cell chemotaxis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060669 [embryonic placenta morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071333 [cellular response to glucose stimulus]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071944 [cell periphery]

739

81.3

Yes

VCAM1-002

ENSP00000304611
ENST00000347652

P19320
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P19320 [Direct mapping]
Vascular cell adhesion protein 1
F8UU18 [Target identity:30%; Query identity:100%]
Vascular cell adhesion molecule 1
G0ZI12 [Target identity:30%; Query identity:100%]
Vascular cell adhesion molecule 1
F8UV74 [Target identity:21%; Query identity:100%]
Vascular cell adhesion molecule 1
Q68DC4 [Target identity:8%; Query identity:100%]
Putative uncharacterized protein DKFZp779G2333
G0ZFQ0 [Target identity:3%; Query identity:100%]
Vascular cell adhesion molecule 1

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GO:0001666 [response to hypoxia]
GO:0002102 [podosome]
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0007155 [cell adhesion]
GO:0007157 [heterophilic cell-cell adhesion]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010212 [response to ionizing radiation]
GO:0016021 [integral to membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022614 [membrane to membrane docking]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042383 [sarcolemma]
GO:0045177 [apical part of cell]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060710 [chorio-allantoic fusion]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071333 [cellular response to glucose stimulus]

647

71.3

Yes

VCAM1-003

ENSP00000359133
ENST00000370115

E9PDD2
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E9PDD2 [Target identity:100%; Query identity:100%]
Vascular cell adhesion protein 1
G0ZI12 [Target identity:36%; Query identity:100%]
Vascular cell adhesion molecule 1
F8UV74 [Target identity:26%; Query identity:100%]
Vascular cell adhesion molecule 1
Q68DC4 [Target identity:9%; Query identity:100%]
Putative uncharacterized protein DKFZp779G2333
G0ZFQ0 [Target identity:3%; Query identity:100%]
Vascular cell adhesion molecule 1

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   1TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral to membrane]
GO:0016337 [cell-cell adhesion]

540

59.2

Yes

VCAM1-004

ENSP00000359137
ENST00000370119

P19320
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P19320 [Direct mapping]
Vascular cell adhesion protein 1
F8UU18 [Target identity:28%; Query identity:100%]
Vascular cell adhesion molecule 1
F2YYR6 [Target identity:26%; Query identity:100%]
Vascular cell adhesion molecule 1
F8UV74 [Target identity:20%; Query identity:100%]
Vascular cell adhesion molecule 1
Q68DC4 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp779G2333
G0ZFQ0 [Target identity:3%; Query identity:100%]
Vascular cell adhesion molecule 1

Show » « Hide

GO:0001666 [response to hypoxia]
GO:0002102 [podosome]
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0007155 [cell adhesion]
GO:0007157 [heterophilic cell-cell adhesion]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010212 [response to ionizing radiation]
GO:0016021 [integral to membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0022614 [membrane to membrane docking]
GO:0030175 [filopodium]
GO:0030183 [B cell differentiation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042383 [sarcolemma]
GO:0045177 [apical part of cell]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0050901 [leukocyte tethering or rolling]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060710 [chorio-allantoic fusion]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071333 [cellular response to glucose stimulus]

677

74.3

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.