IL24

GENE INFORMATION

? »

Gene name

IL24 (HGNC Symbol)

Synonyms

C49A, FISP, IL-24, IL10B, mda-7, Mob-5, ST16

Description

Interleukin 24 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

207070788 - 207077484

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162892 (version 75.37)

Entrez gene

11009

UniProt

Q13007 (UniProt - Evidence at protein level)

neXtProt

NX_Q13007

Antibodypedia

IL24 antibodies
 

PROTEIN VIEW

? »
 
 
 
IL24-001
 
IL24-002
 
IL24-004
 
IL24-005
 
IL24-006
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL24-001 ENSP00000294984
ENST00000294984
Q13007
Show all »
Show » Show » 206 23.8 Yes 0
IL24-002 ENSP00000375795
ENST00000391929
Q13007
Show all »
Show » Show » 207 23.9 Yes 0
IL24-004 ENSP00000356062
ENST00000367095
E7ER64
Show all »
51 5.9 No 0
IL24-005 ENSP00000356060
ENST00000367093
Q13007
Show all »
Show » Show » 154 17.8 Yes 0
IL24-006 ENSP00000418933
ENST00000480741
E7ETP6
Show all »
60 7 No 0