H2AFZ

GENE INFORMATION

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Gene name

H2AFZ (HGNC Symbol)

Synonyms

H2A.Z, H2AZ

Description

H2A histone family, member Z (HGNC Symbol)

Entrez gene summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q23

Chromosome location (bp)

100869243 - 100871545

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164032 (version 75.37)

Entrez gene

3015

UniProt

P0C0S5 (UniProt - Evidence at protein level)

neXtProt

NX_P0C0S5

Antibodypedia

H2AFZ antibodies
 

PROTEIN VIEW

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H2AFZ-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

H2AFZ-001 ENSP00000296417
ENST00000296417
P0C0S5
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