GRM2

GENE INFORMATION

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Gene name

GRM2 (HGNC Symbol)

Synonyms

GPRC1B, mGlu2, MGLUR2

Description

Glutamate receptor, metabotropic 2 (HGNC Symbol)

Entrez gene summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.2

Chromosome location (bp)

51741086 - 51752629

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164082 (version 75.37)

Entrez gene

2912

UniProt

Q14416 (UniProt - Evidence at protein level)

neXtProt

NX_Q14416

Antibodypedia

GRM2 antibodies
 

PROTEIN VIEW

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GRM2-001
 
GRM2-002
 
GRM2-005
 
GRM2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRM2-001 ENSP00000378492
ENST00000395052
Q14416
Show all »
Show » Show » 872 95.6 Yes 7
GRM2-002 ENSP00000296479
ENST00000296479
H7BXL3
Show all »
Show » Show » 435 47.8 Yes 0
GRM2-005 ENSP00000408906
ENST00000442933
C9JL63
Show all »
Show » Show » 594 65.5 Yes 2
GRM2-007 ENSP00000404797
ENST00000419928
C9JD41
Show all »
Show » Show » 70 7.3 Yes 0