NDUFS4

GENE INFORMATION

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Gene name

NDUFS4 (HGNC Symbol)

Synonyms

AQDQ, CI-18

Description

NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q11.2

Chromosome location (bp)

52856463 - 52979168

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164258 (version 75.37)

Entrez gene

4724

UniProt

O43181 (UniProt - Evidence at protein level)

neXtProt

NX_O43181

Antibodypedia

NDUFS4 antibodies
 

PROTEIN VIEW

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NDUFS4-001
 
NDUFS4-002
 
NDUFS4-003
 
NDUFS4-004
 
NDUFS4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFS4-001 ENSP00000296684
ENST00000296684
O43181
Show all »
Show » Show » 175 20.1 No 0
NDUFS4-002 ENSP00000422177
ENST00000502423
D6R916
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Show » Show » 73 8.3 No 0
NDUFS4-003 ENSP00000424993
ENST00000507026
D6REP1
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Show » Show » 49 5.4 No 0
NDUFS4-004 ENSP00000425967
ENST00000506974
D6RI09
Show all »
Show » Show » 131 14.9 No 1
NDUFS4-005 ENSP00000424570
ENST00000506765
H0Y9M8
Show all »
Show » Show » 116 13.5 No 0