GFM2

GENE INFORMATION

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Gene name

GFM2 (HGNC Symbol)

Synonyms

EFG2, FLJ21661

Description

G elongation factor, mitochondrial 2 (HGNC Symbol)

Entrez gene summary

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

Chromosome

5

Cytoband

q13.3

Chromosome location (bp)

74017029 - 74063196

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164347 (version 75.37)

Entrez gene

84340

UniProt

Q969S9 (UniProt - Evidence at protein level)

neXtProt

NX_Q969S9

Antibodypedia

GFM2 antibodies
 

PROTEIN VIEW

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GFM2-001
 
GFM2-002
 
GFM2-003
 
GFM2-004
 
GFM2-005
 
GFM2-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GFM2-001 ENSP00000296805
ENST00000296805
Q969S9
Show all »
Show » Show » 779 86.6 No 0
GFM2-002 ENSP00000296804
ENST00000345239
Q969S9
Show all »
Show » Show » 732 81.2 No 0
GFM2-003 ENSP00000405808
ENST00000427854
Q969S9
Show all »
Show » Show » 513 57.1 No 0
GFM2-004 ENSP00000427004
ENST00000509430
Q969S9
Show all »
Show » Show » 779 86.6 No 0
GFM2-005 ENSP00000421717
ENST00000509097
D6RAL1
Show all »
Show » Show » 285 31.9 No 0
GFM2-011 ENSP00000424877
ENST00000506778
D6RF75
Show all »
Show » Show » 64 7.2 No 0