DEFA4

GENE INFORMATION

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Gene name

DEFA4 (HGNC Symbol)

Synonyms

DEF4, HP-4

Description

Defensin, alpha 4, corticostatin (HGNC Symbol)

Entrez gene summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

6793344 - 6795860

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164821 (version 75.37)

Entrez gene

1669

UniProt

P12838 (UniProt - Evidence at protein level)

neXtProt

NX_P12838

Antibodypedia

DEFA4 antibodies
 

PROTEIN VIEW

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DEFA4-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEFA4-001 ENSP00000297435
ENST00000297435
P12838
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