ILK - Gene info - The Human Protein Atlas

Gene name

ILK

Synonyms

Description

Integrin-linked kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

Cytoband

p15.4

Chromosome location (bp)

6624961 - 6632102

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166333 (version 75.37)

Entrez gene

3611

UniProt

Q13418 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ILK-001

ENSP00000299421
ENST00000299421

Q13418
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Q13418 [Direct mapping]
Integrin-linked protein kinase
B7Z1I0 [Target identity:70%; Query identity:100%]
Integrin-linked protein kinase; cDNA FLJ53825, highly similar to Integrin-linked protein kinase 1

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   Transferases
   TKL Ser/Thr protein kinases
Enzymes
   ENZYME proteins
   Kinases
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007050 [cell cycle arrest]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007569 [cell aging]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009966 [regulation of signal transduction]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017124 [SH3 domain binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0021675 [nerve development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032288 [myelin assembly]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0043025 [neuronal cell body]
GO:0043034 [costamere]
GO:0043195 [terminal bouton]
GO:0043198 [dendritic shaft]
GO:0043206 [extracellular fibril organization]
GO:0043234 [protein complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043491 [protein kinase B signaling cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0051291 [protein heterooligomerization]
GO:0051897 [positive regulation of protein kinase B signaling cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]

452

51.4

ILK-002

ENSP00000403487
ENST00000420936

Q13418
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452

51.4

ILK-003

ENSP00000379975
ENST00000396751

Q13418
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GO:0001558 [regulation of cell growth]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007050 [cell cycle arrest]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007569 [cell aging]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009966 [regulation of signal transduction]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014044 [Schwann cell development]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017124 [SH3 domain binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0021675 [nerve development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032288 [myelin assembly]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0043025 [neuronal cell body]
GO:0043034 [costamere]
GO:0043066 [negative regulation of apoptotic process]
GO:0043195 [terminal bouton]
GO:0043198 [dendritic shaft]
GO:0043206 [extracellular fibril organization]
GO:0043234 [protein complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0051291 [protein heterooligomerization]
GO:0051897 [positive regulation of protein kinase B signaling cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]

452

51.4

ILK-004

ENSP00000432796
ENST00000527327

E9PNR4
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E9PNR4 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase
E9PM54 [Target identity:95%; Query identity:100%]
Integrin-linked protein kinase

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

219

24.4

ILK-005

ENSP00000435323
ENST00000528995

B7Z418
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B7Z418 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase; cDNA FLJ50979, moderately similar to Integrin-linked protein kinase

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007229 [integrin-mediated signaling pathway]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

391

44.3

ILK-006

ENSP00000434492
ENST00000532063

E9PQ27
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E9PQ27 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

4.6

ILK-007

ENSP00000433129
ENST00000527394

E9PM54
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E9PM54 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

209

23.1

ILK-008

ENSP00000436062
ENST00000527121

E9PQ52
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E9PQ52 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

4.1

ILK-009

ENSP00000432617
ENST00000526114

E9PQ52
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E9PQ52 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

4.1

ILK-201

ENSP00000439606
ENST00000537806

B7Z1I0
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B7Z1I0 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase; cDNA FLJ53825, highly similar to Integrin-linked protein kinase 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005178 [integrin binding]
GO:0005524 [ATP binding]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007050 [cell cycle arrest]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007569 [cell aging]
GO:0008284 [positive regulation of cell proliferation]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017124 [SH3 domain binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0021675 [nerve development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032288 [myelin assembly]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0043025 [neuronal cell body]
GO:0043034 [costamere]
GO:0043195 [terminal bouton]
GO:0043198 [dendritic shaft]
GO:0043206 [extracellular fibril organization]
GO:0043234 [protein complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043491 [protein kinase B signaling cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0051291 [protein heterooligomerization]
GO:0051897 [positive regulation of protein kinase B signaling cascade]

318

36.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.