B2M - Gene info - The Human Protein Atlas

Gene name

B2M

Synonyms

Description

Beta-2-microglobulin (HGNC Symbol)

Entrez gene summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Chromosome

Cytoband

q21.1

Chromosome location (bp)

45003675 - 45011075

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166710 (version 75.37)

Entrez gene

567

UniProt

P61769 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B2M-001

ENSP00000452780
ENST00000558401

P61769
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P61769 [Direct mapping]
Beta-2-microglobulin Beta-2-microglobulin form pI 5.3
A6XND9 [Target identity:84%; Query identity:100%]
Beta-2-microglobulin
H0YLF3 [Target identity:59%; Query identity:100%]
Beta-2-microglobulin form pI 5.3
Q9UM88 [Target identity:24%; Query identity:100%]
Beta 2-microglobulin protein

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000139 [Golgi membrane]
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002237 [response to molecule of bacterial origin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0009897 [external side of plasma membrane]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030670 [phagocytic vesicle membrane]
GO:0031901 [early endosome membrane]
GO:0031905 [early endosome lumen]
GO:0033077 [T cell differentiation in thymus]
GO:0042026 [protein refolding]
GO:0042493 [response to drug]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042612 [MHC class I protein complex]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0046686 [response to cadmium ion]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]

119

13.7

Yes

B2M-002

ENSP00000453023
ENST00000559720

F5H6I0
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F5H6I0 [Target identity:100%; Query identity:100%]
Beta-2-microglobulin
Q9UM88 [Target identity:23%; Query identity:100%]
Beta 2-microglobulin protein

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0042612 [MHC class I protein complex]

122

Yes

B2M-003

ENSP00000452861
ENST00000557901

Q16446
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Q16446 [Target identity:100%; Query identity:100%]
Beta 2-microglobulin protein; Beta-2-microglobulin form pI 5.3; Beta-2-microglobulin, isoform CRA_a

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005576 [extracellular region]
GO:0006955 [immune response]

5.6

Yes

B2M-006

ENSP00000453350
ENST00000559916

P61769
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119

13.7

Yes

B2M-007

ENSP00000340858
ENST00000349264

J3KNU0
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J3KNU0 [Target identity:100%; Query identity:100%]
Beta-2-microglobulin form pI 5.3

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6.1

Yes

B2M-011

ENSP00000453186
ENST00000561139

H0YLF3
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H0YLF3 [Target identity:100%; Query identity:100%]
Beta-2-microglobulin form pI 5.3

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Cancer-related genes
Mutated cancer genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002237 [response to molecule of bacterial origin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0009897 [external side of plasma membrane]
GO:0033077 [T cell differentiation in thymus]
GO:0042026 [protein refolding]
GO:0042493 [response to drug]
GO:0042612 [MHC class I protein complex]
GO:0046686 [response to cadmium ion]

8.5

B2M-013

ENSP00000453191
ENST00000561424

P61769
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119

13.7

Yes

B2M-201

ENSP00000437604
ENST00000544417

F5H6I0
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F5H6I0 [Target identity:100%; Query identity:100%]
Beta-2-microglobulin
Q9UM88 [Target identity:23%; Query identity:100%]
Beta 2-microglobulin protein

Show » « Hide

   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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122

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.