CHP2

GENE INFORMATION

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Gene name

CHP2

Synonyms

Description

Calcineurin-like EF-hand protein 2 (HGNC Symbol)

Entrez gene summary

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

Chromosome

16

Cytoband

p12.2

Chromosome location (bp)

23765948 - 23770272

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166869 (version 75.37)

Entrez gene

63928

UniProt

O43745 (UniProt - Evidence at protein level)

neXtProt

NX_O43745

Antibodypedia

CHP2 antibodies
 

PROTEIN VIEW

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CHP2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHP2-001 ENSP00000300113
ENST00000300113
O43745
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