GREM1

GENE INFORMATION

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Gene name

GREM1 (HGNC Symbol)

Synonyms

CKTSF1B1, DAND2, DRM, gremlin

Description

Gremlin 1, DAN family BMP antagonist (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

15

Cytoband

q13.3

Chromosome location (bp)

33010175 - 33026870

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166923 (version 75.37)

Entrez gene

26585

UniProt

O60565 (UniProt - Evidence at protein level)

neXtProt

NX_O60565

Antibodypedia

GREM1 antibodies
 

PROTEIN VIEW

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GREM1-001
 
GREM1-002
 
GREM1-005
 
GREM1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GREM1-001 ENSP00000300177
ENST00000300177
O60565
Show all »
Show » Show » 184 20.7 Yes 0
GREM1-002 ENSP00000453141
ENST00000560830
O60565
Show all »
Show » Show » 143 16.3 Yes 0
GREM1-005 ENSP00000453387
ENST00000560677
H0YLY2
Show all »
Show » 42 4.3 Yes 0
GREM1-201 ENSP00000323101
ENST00000322805
O60565
Show all »
Show » Show » 143 16.3 Yes 0