CYP7A1

GENE INFORMATION

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Gene name

CYP7A1 (HGNC Symbol)

Synonyms

CYP7

Description

Cytochrome P450, family 7, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

Chromosome

8

Cytoband

q12.1

Chromosome location (bp)

59402737 - 59412795

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167910 (version 75.37)

Entrez gene

1581

UniProt

P22680 (UniProt - Evidence at protein level)

neXtProt

NX_P22680

Antibodypedia

CYP7A1 antibodies
 

PROTEIN VIEW

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CYP7A1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP7A1-001 ENSP00000301645
ENST00000301645
P22680
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