PDHB

GENE INFORMATION

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Gene name

PDHB

Synonyms

Description

Pyruvate dehydrogenase (lipoamide) beta (HGNC Symbol)

Entrez gene summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]

Chromosome

3

Cytoband

p14.3

Chromosome location (bp)

58413357 - 58419584

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168291 (version 75.37)

Entrez gene

5162

UniProt

P11177 (UniProt - Evidence at protein level)

neXtProt

NX_P11177

Antibodypedia

PDHB antibodies
 

PROTEIN VIEW

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PDHB-001
 
PDHB-005
 
PDHB-006
 
PDHB-007
 
PDHB-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDHB-001 ENSP00000307241
ENST00000302746
P11177
Show all »
Show » Show » 359 39.2 No 0
PDHB-005 ENSP00000417267
ENST00000485460
P11177
Show all »
Show » Show » 341 37.5 No 0
PDHB-006 ENSP00000419580
ENST00000469364
F8WF02
Show all »
Show » 251 27.7 No 0
PDHB-007 ENSP00000418448
ENST00000474765
C9J634
Show all »
Show » Show » 350 38.4 No 0
PDHB-008 ENSP00000373220
ENST00000383714
P11177
Show all »
Show » Show » 341 37.2 No 0