MTNR1A

GENE INFORMATION

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Gene name

MTNR1A (HGNC Symbol)

Synonyms

MEL-1A-R

Description

Melatonin receptor 1A (HGNC Symbol)

Entrez gene summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q35.2

Chromosome location (bp)

187454809 - 187476721

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168412 (version 75.37)

Entrez gene

4543

UniProt

P48039 (UniProt - Evidence at protein level)

neXtProt

NX_P48039

Antibodypedia

MTNR1A antibodies
 

PROTEIN VIEW

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MTNR1A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTNR1A-001 ENSP00000302811
ENST00000307161
P48039
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