FEN1

GENE INFORMATION

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Gene name

FEN1 (HGNC Symbol)

Synonyms

FEN-1, MF1, RAD2

Description

Flap structure-specific endonuclease 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.2

Chromosome location (bp)

61560109 - 61564716

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168496 (version 75.37)

Entrez gene

2237

UniProt

P39748 (UniProt - Evidence at protein level)

neXtProt

NX_P39748

Antibodypedia

FEN1 antibodies
 

PROTEIN VIEW

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FEN1-001
 
FEN1-003
 
FEN1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FEN1-001 ENSP00000305480
ENST00000305885
P39748
Show all »
Show » Show » 380 42.6 No 0
FEN1-003 ENSP00000445692
ENST00000535723
F5H1Y3
Show all »
Show » Show » 165 18.3 No 0
FEN1-004 ENSP00000460402
ENST00000535307
Show » Show » 154 17.8 No 0