ROR2

GENE INFORMATION

? »

Gene name

ROR2 (HGNC Symbol)

Synonyms

BDB, BDB1, NTRKR2

Description

Receptor tyrosine kinase-like orphan receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q22.31

Chromosome location (bp)

94325373 - 94712444

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169071 (version 75.37)

Entrez gene

4920

UniProt

Q01974 (UniProt - Evidence at protein level)

neXtProt

NX_Q01974

Antibodypedia

ROR2 antibodies
 

PROTEIN VIEW

? »
 
 
 
ROR2-001
 
ROR2-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ROR2-001 ENSP00000364860
ENST00000375708
Q01974
Show all »
Show » Show » 943 104.8 Yes 1
ROR2-002 ENSP00000364867
ENST00000375715
B1APY4
Show all »
Show » Show » 704 79.3 No 1