DFFB

GENE INFORMATION

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Gene name

DFFB (HGNC Symbol)

Synonyms

CAD, CPAN, DFF-40, DFF40

Description

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (HGNC Symbol)

Entrez gene summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]

Chromosome

1

Cytoband

p36.32

Chromosome location (bp)

3773845 - 3801993

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169598 (version 75.37)

Entrez gene

1677

UniProt

O76075 (UniProt - Evidence at protein level)

neXtProt

NX_O76075

Antibodypedia

DFFB antibodies
 

PROTEIN VIEW

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 « 
 
DFFB-001
 
DFFB-002
 
DFFB-003
 
DFFB-004
 
DFFB-005
 
DFFB-006
 
DFFB-007
 
DFFB-009
 
DFFB-201
 
DFFB-202
 
DFFB-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DFFB-001 ENSP00000367454
ENST00000378209
O76075
Show all »
Show » Show » 338 39.1 No 0
DFFB-002 ENSP00000463688
ENST00000468793
Q96P73
Show all »
Show » Show » 115 12.8 No 0
DFFB-003 ENSP00000462175
ENST00000477548
G3XAD0
Show all »
Show » Show » 103 11.5 No 0
DFFB-004 ENSP00000343218
ENST00000339350
O76075
Show all »
Show » Show » 116 12.8 No 0
DFFB-005 ENSP00000436775
ENST00000491998
O76075
Show all »
Show » Show » 270 30.6 No 0
DFFB-006 ENSP00000463704
ENST00000475969
Q96P73
Show all »
Show » Show » 115 12.8 No 0
DFFB-007 ENSP00000367448
ENST00000378206
Q96P72
Show all »
Show » Show » 80 9.1 No 0
DFFB-009 ENSP00000462770
ENST00000461150
Show » Show » 78 9.3 No 0
DFFB-201 ENSP00000339524
ENST00000338895
O76075
Show all »
Show » Show » 270 30.6 No 0
DFFB-202 ENSP00000345906
ENST00000341385
G3XAD0
Show all »
Show » Show » 103 11.5 No 0
DFFB-203 ENSP00000367457
ENST00000378212
O76075
Show all »
Show » Show » 116 12.8 No 0