HOXD4

GENE INFORMATION

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Gene name

HOXD4 (HGNC Symbol)

Synonyms

HOX4, HOX4B

Description

Homeobox D4 (HGNC Symbol)

Entrez gene summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

177015950 - 177017954

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170166 (version 75.37)

Entrez gene

3233

UniProt

P09016 (UniProt - Evidence at transcript level)

neXtProt

NX_P09016

Antibodypedia

HOXD4 antibodies
 

PROTEIN VIEW

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HOXD4-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOXD4-001 ENSP00000302548
ENST00000306324
P09016
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