UBB

GENE INFORMATION

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Gene name

UBB (HGNC Symbol)

Synonyms

FLJ25987, MGC8385

Description

Ubiquitin B (HGNC Symbol)

Entrez gene summary

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

16284112 - 16286059

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170315 (version 75.37)

Entrez gene

7314

UniProt

P0CG47 (UniProt - Evidence at protein level)

neXtProt

NX_P0CG47

Antibodypedia

UBB antibodies
 

PROTEIN VIEW

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UBB-001
 
UBB-002
 
UBB-003
 
UBB-005
 
UBB-006
 
UBB-007
 
UBB-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBB-001 ENSP00000304697
ENST00000302182
P0CG47
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Show » 229 25.8 No 0
UBB-002 ENSP00000379178
ENST00000395837
P0CG47
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Show » 229 25.8 No 0
UBB-003 ENSP00000379180
ENST00000395839
P0CG47
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Show » 229 25.8 No 0
UBB-005 ENSP00000437475
ENST00000535788
B4DV12
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Show » 153 17.2 No 0
UBB-006 ENSP00000464594
ENST00000577958
J3QSA3
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Show » 43 4.9 No 0
UBB-007 ENSP00000464510
ENST00000578706
J3QS39
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Show » 93 10.5 No 0
UBB-008 ENSP00000463156
ENST00000577640
J3QKN0
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Show » 206 23.2 No 0