KISS1

GENE INFORMATION

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Gene name

KISS1

Synonyms

Description

KiSS-1 metastasis-suppressor (HGNC Symbol)

Entrez gene summary

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

204159469 - 204165614

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170498 (version 75.37)

Entrez gene

3814

UniProt

Q15726 (UniProt - Evidence at protein level)

neXtProt

NX_Q15726

Antibodypedia

KISS1 antibodies
 

PROTEIN VIEW

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KISS1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KISS1-001 ENSP00000356162
ENST00000367194
Q15726
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