CEL

GENE INFORMATION

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Gene name

CEL (HGNC Symbol)

Synonyms

BSSL, MODY8

Description

Carboxyl ester lipase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

135937365 - 135947248

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170835 (version 75.37)

Entrez gene

1056

UniProt

P19835 (UniProt - Evidence at protein level)

neXtProt

NX_P19835

Antibodypedia

CEL antibodies
 

PROTEIN VIEW

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CEL-001
 
CEL-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CEL-001 ENSP00000361151
ENST00000372080
Q9UMB1
Show all »
Show » Show » 756 79.7 Yes 0
CEL-201 ENSP00000342217
ENST00000351304
P19835
Show all »
Show » Show » 687 71.8 Yes 0