GRIK1 - Gene info - The Human Protein Atlas

Gene name

GRIK1 (HGNC Symbol)

Synonyms

GluK1, GLUR5

Description

Glutamate receptor, ionotropic, kainate 1 (HGNC Symbol)

Entrez gene summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q21.3

Chromosome location (bp)

30909254 - 31312351

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171189 (version 75.37)

Entrez gene

2897

UniProt

P39086 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRIK1-001

ENSP00000373777
ENST00000389125

P39086
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P39086 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
D3DSE2 [Target identity:54%; Query identity:100%]
Glutamate receptor, ionotropic, kainate 1, isoform CRA_b
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   3TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)

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GO:0004970 [ionotropic glutamate receptor activity]
GO:0005215 [transporter activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006810 [transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0014054 [positive regulation of gamma-aminobutyric acid secretion]
GO:0015277 [kainate selective glutamate receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
GO:0048266 [behavioral response to pain]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060079 [regulation of excitatory postsynaptic membrane potential]
GO:0060080 [regulation of inhibitory postsynaptic membrane potential]

905

102.6

GRIK1-002

ENSP00000382791
ENST00000399907

P39086
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P39086 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Q71UA3 [Target identity:5%; Query identity:100%]
Glutamate receptor
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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GO:0004970 [ionotropic glutamate receptor activity]
GO:0005215 [transporter activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006810 [transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0014054 [positive regulation of gamma-aminobutyric acid secretion]
GO:0015277 [kainate selective glutamate receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042391 [regulation of membrane potential]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
GO:0048266 [behavioral response to pain]
GO:0051899 [membrane depolarization]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060079 [regulation of excitatory postsynaptic membrane potential]
GO:0060080 [regulation of inhibitory postsynaptic membrane potential]

918

104

GRIK1-003

ENSP00000382798
ENST00000399914

E7EPY9
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E7EPY9 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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GO:0004970 [ionotropic glutamate receptor activity]
GO:0005215 [transporter activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral to membrane]
GO:0030054 [cell junction]
GO:0045211 [postsynaptic membrane]

934

106.2

GRIK1-004

ENSP00000327687
ENST00000327783

E7ENK3
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E7ENK3 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
Q71UA3 [Target identity:5%; Query identity:100%]
Glutamate receptor
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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949

107.9

GRIK1-005

ENSP00000373776
ENST00000389124

H7BYG7
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H7BYG7 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
Q71UA3 [Target identity:5%; Query identity:100%]
Glutamate receptor
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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871

98.8

GRIK1-006

ENSP00000382797
ENST00000399913

E9PD61
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E9PD61 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
D3DSE2 [Target identity:53%; Query identity:100%]
Glutamate receptor, ionotropic, kainate 1, isoform CRA_b
Q71UA3 [Target identity:5%; Query identity:100%]
Glutamate receptor
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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920

104.4

GRIK1-008

ENSP00000382793
ENST00000399909

E7EPZ0
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E7EPZ0 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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903

102.3

GRIK1-201

ENSP00000311646
ENST00000309434

F8W7X3
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F8W7X3 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
Q71UA3 [Target identity:5%; Query identity:100%]
Glutamate receptor
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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920

104.2

GRIK1-202

ENSP00000446326
ENST00000535441

F5H1W5
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F5H1W5 [Target identity:100%; Query identity:100%]
Glutamate receptor ionotropic, kainate 1
D3DSE2 [Target identity:53%; Query identity:100%]
Glutamate receptor, ionotropic, kainate 1, isoform CRA_b
Q71UA3 [Target identity:5%; Query identity:100%]
Glutamate receptor
Q9UNN1 [Target identity:4%; Query identity:100%]
GRIK1 protein; Glutamate receptor

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922

104.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.