PROL1

GENE INFORMATION

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Gene name

PROL1 (HGNC Symbol)

Synonyms

BPLP, opiorphin, PRL1

Description

Proline rich, lacrimal 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

71263599 - 71275911

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171199 (version 75.37)

Entrez gene

58503

UniProt

Q99935 (UniProt - Evidence at protein level)

neXtProt

NX_Q99935

Antibodypedia

PROL1 antibodies
 

PROTEIN VIEW

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PROL1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PROL1-001 ENSP00000382485
ENST00000399575
Q99935
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