MYD88 - Gene info - The Human Protein Atlas

Gene name

MYD88

Synonyms

Description

Myeloid differentiation primary response 88 (HGNC Symbol)

Entrez gene summary

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Chromosome

Cytoband

p22.2

Chromosome location (bp)

38179969 - 38184513

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172936 (version 75.37)

Entrez gene

4615

UniProt

Q99836 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYD88-001

ENSP00000379625
ENST00000396334

J3KPU4
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J3KPU4 [Target identity:100%; Query identity:100%]
Myeloid differentiation primary response gene (88), isoform CRA_b; Myeloid differentiation primary response protein MyD88
B4E3D6 [Target identity:92%; Query identity:100%]
cDNA FLJ56294, highly similar to Myeloid differentiation primary responseprotein MyD88

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   COSMIC Missense Mutations
   COSMIC Somatic Mutations
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0032481 [positive regulation of type I interferon production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071260 [cellular response to mechanical stimulus]

309

34.6

MYD88-006

ENSP00000391753
ENST00000421516

H0Y4G9
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H0Y4G9 [Target identity:100%; Query identity:100%]
Myeloid differentiation primary response protein MyD88

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GO:0002238 [response to molecule of fungal origin]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005121 [Toll binding]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0008063 [Toll signaling pathway]
GO:0009615 [response to virus]
GO:0014069 [postsynaptic density]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045080 [positive regulation of chemokine biosynthetic process]
GO:0045351 [type I interferon biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070976 [TIR domain binding]

316

35.3

MYD88-008

ENSP00000417848
ENST00000495303

Q99836
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Q99836 [Direct mapping]
Myeloid differentiation primary response protein MyD88

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   THUMBUP predicted membrane proteins
   COSMIC Missense Mutations
   COSMIC Somatic Mutations
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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159

17.2

MYD88-009

ENSP00000390565
ENST00000443433

Q99836
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Q99836 [Direct mapping]
Myeloid differentiation primary response protein MyD88

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   SCAMPI predicted membrane proteins
   COSMIC Missense Mutations
   COSMIC Somatic Mutations
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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204

22.1

MYD88-011

ENSP00000389979
ENST00000424893

J3KQ87
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J3KQ87 [Target identity:100%; Query identity:100%]
Myeloid differentiation primary response protein MyD88

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GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070976 [TIR domain binding]

264

29.6

MYD88-201

ENSP00000401399
ENST00000417037

J3KQJ6
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J3KQJ6 [Target identity:100%; Query identity:100%]
Myeloid differentiation primary response protein MyD88
H0Y4G9 [Target identity:99%; Query identity:100%]
Myeloid differentiation primary response protein MyD88

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GO:0002238 [response to molecule of fungal origin]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005102 [receptor binding]
GO:0005121 [Toll binding]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007254 [JNK cascade]
GO:0008063 [Toll signaling pathway]
GO:0009615 [response to virus]
GO:0014069 [postsynaptic density]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0042127 [regulation of cell proliferation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045080 [positive regulation of chemokine biosynthetic process]
GO:0045351 [type I interferon biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070976 [TIR domain binding]

317

35.4

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.