DAB1 - Gene info - The Human Protein Atlas

Gene name

DAB1

Synonyms

Description

Dab, reelin signal transducer, homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p32.1

Chromosome location (bp)

57460451 - 59012406

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173406 (version 75.37)

Entrez gene

1600

UniProt

O75553 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAB1-004

ENSP00000360280
ENST00000371236

O75553
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O75553 [Direct mapping]
Disabled homolog 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021795 [cerebral cortex cell migration]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0021987 [cerebral cortex development]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]
GO:0097477 [lateral motor column neuron migration]

555

59.9

DAB1-005

ENSP00000360274
ENST00000371230

O75553
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O75553 [Direct mapping]
Disabled homolog 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]

213

24.1

DAB1-007

ENSP00000360276
ENST00000371232

Q8NFD0
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Q8NFD0 [Target identity:13%; Query identity:100%]
DAB1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

239

25.7

DAB1-008

ENSP00000329120
ENST00000332102

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

204

22.9

DAB1-010

ENSP00000360275
ENST00000371231

O75553
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O75553 [Direct mapping]
Disabled homolog 1
Q8NFD0 [Target identity:5%; Query identity:100%]
DAB1

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]

588

63.8

DAB1-201

ENSP00000360278
ENST00000371234

O75553
Show all » « Hide

O75553 [Direct mapping]
Disabled homolog 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]

555

59.9

DAB1-202

ENSP00000387581
ENST00000414851

O75553
Show all » « Hide

O75553 [Direct mapping]
Disabled homolog 1

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]

537

57.7

DAB1-203

ENSP00000395296
ENST00000420954

O75553
Show all » « Hide

O75553 [Direct mapping]
Disabled homolog 1
Q8NFD0 [Target identity:5%; Query identity:100%]
DAB1

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]

553

59.6

DAB1-204

ENSP00000409328
ENST00000439789

O75553
Show all » « Hide

O75553 [Direct mapping]
Disabled homolog 1
Q8NFD0 [Target identity:7%; Query identity:100%]
DAB1

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007494 [midgut development]
GO:0007628 [adult walking behavior]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0021517 [ventral spinal cord development]
GO:0021589 [cerebellum structural organization]
GO:0021813 [cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration]
GO:0021942 [radial glia guided migration of Purkinje cell]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045177 [apical part of cell]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0050771 [negative regulation of axonogenesis]
GO:0051645 [Golgi localization]

469

49.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.