PSMD1 - Gene info - The Human Protein Atlas

PSMD1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PSMD1 (HGNC Symbol)
Synonyms	P112, Rpn2, S1
Description	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 (HGNC Symbol)
Entrez gene summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	231921578 - 232037541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173692 (version 75.37)
Entrez gene	5707
UniProt	Q99460 (UniProt - Evidence at protein level)
neXtProt	NX_Q99460
Antibodypedia	PSMD1 antibodies

PROTEIN VIEW

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PSMD1-001		PSMD1-002		PSMD1-003		PSMD1-005		PSMD1-006		PSMD1-009		PSMD1-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PSMD1-001	ENSP00000309474 ENST00000308696	Q99460 Show all » « Hide Q99460 [Direct mapping] 26S proteasome non-ATPase regulatory subunit 1	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005838 [proteasome regulatory particle] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0022624 [proteasome accessory complex] GO:0030234 [enzyme regulator activity] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]	953	105.8	No	1
PSMD1-002	ENSP00000400483 ENST00000431051	F8WCE3 Show all » « Hide F8WCE3 [Target identity:100%; Query identity:100%] 26S proteasome non-ATPase regulatory subunit 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	5.4	No	0
PSMD1-003	ENSP00000386932 ENST00000409643	Q99460 Show all » « Hide Q99460 [Direct mapping] 26S proteasome non-ATPase regulatory subunit 1	Show » « Hide MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005838 [proteasome regulatory particle] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0022624 [proteasome accessory complex] GO:0030234 [enzyme regulator activity] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]	922	102.3	No	0
PSMD1-005	ENSP00000406141 ENST00000440838	C9J9M4 Show all » « Hide C9J9M4 [Target identity:100%; Query identity:100%] 26S proteasome non-ATPase regulatory subunit 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		203	23.1	No	0
PSMD1-006	ENSP00000390967 ENST00000444007		Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		164	18.3	No	0
PSMD1-009	ENSP00000410061 ENST00000447633		Show » « Hide SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005488 [binding]	192	20.3	Yes	0
PSMD1-201	ENSP00000362738 ENST00000373635	Q99460 Show all » « Hide Q99460 [Direct mapping] 26S proteasome non-ATPase regulatory subunit 1	Show » « Hide MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005838 [proteasome regulatory particle] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0022624 [proteasome accessory complex] GO:0030234 [enzyme regulator activity] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]	922	102.3	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.