RNF213

GENE INFORMATION

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Gene name

RNF213 (HGNC Symbol)

Synonyms

C17orf27, KIAA1554, KIAA1618, MYMY2, NET57

Description

Ring finger protein 213 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

78234665 - 78372586

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173821 (version 75.37)

Entrez gene

57674

UniProt

Q63HN8 (UniProt - Evidence at protein level)

neXtProt

NX_Q63HN8

Antibodypedia

RNF213 antibodies
 

PROTEIN VIEW

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RNF213-001
 
RNF213-002
 
RNF213-015
 
RNF213-020
 
RNF213-201
 
RNF213-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RNF213-001 ENSP00000425956
ENST00000508628
Q63HN8
Show all »
Show » Show » 5256 596.5 No 3
RNF213-002 ENSP00000324392
ENST00000319921
Q63HN8
Show all »
Show » Show » 1063 118.4 No 0
RNF213-015 ENSP00000460462
ENST00000573038
Show » 106 11.7 No 0
RNF213-020 ENSP00000464087
ENST00000582970
Q63HN8
Show all »
Show » Show » 5207 591.4 No 3
RNF213-201 ENSP00000338218
ENST00000336301
H3BLU6
Show all »
Show » Show » 3280 374 No 3
RNF213-202 ENSP00000392123
ENST00000456466
J3QTP8
Show all »
Show » 1550 174.9 No 0